Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
نویسندگان
چکیده
منابع مشابه
Chromosomal Instability, Aneuploidy, and Cancer
The link between aneuploidy and cancer has been recognized over a century ago (1). Abnormalities in chromosome copy numbers arise from persistent errors in chromosome segregation during cell division, a process known as chromosomal instability (CIN) (2). CIN is a principal contributor to genetic heterogeneity in cancer (3) and is an important determinant of clinical prognosis and therapeutic re...
متن کاملCan chromosomal instability initiate tumorigenesis?
Cancers result from the accumulation of inherited and somatic mutations in oncogenes and tumor suppressor genes. These genes encode proteins that function in growth regulatory and differentiation pathways. Mutations in those genes increase the net reproductive rate of cells. Chromosomal instability (CIN) is a feature of most human cancers. Mutations in CIN genes increase the rate at which whole...
متن کاملChromosomes and Cancer, Boveri Revisited
Already in the late 19th century, the link between chromosomal aberrations and the pathogenesis of cancer was described by von Hanssemann [9]. Moreover, as early as the first decade of the 20th century the German zoologist Theodor Boveri developed a genetic theory of cancer based on these chromosomal aberrations [3]. Until quite recently, these ideas have received only limited attention and foc...
متن کاملChromosomal instability and aneuploidy in cancer: from yeast to man.
Aneuploidy is frequently associated with disease and developmental abnormalities. It is also a key characteristic of cancer. Several model systems have been developed to study the role of chromosomal instability and aneuploidy in tumorigenesis. The results are surprisingly complex, with the conditions sometimes promoting and sometimes inhibiting tumour formation. Here, we review the effects of ...
متن کاملRe-replication of a Centromere Induces Chromosomal Instability and Aneuploidy
The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performed with a high degree of fidelity. The fidelity of chromosomal replication is maintained in part by re-replication controls that ensure there are no more than two copies of every genomic segment to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2009
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2718